Neurofibrillary Tangles May Interfere With Smad 2/3 Signaling in Neurons
نویسندگان
چکیده
منابع مشابه
Neurofibrillary tangles may interfere with Smad 2/3 signaling in neurons.
Transforming growth factor (TGF)-beta is a multifunctional cytokine with anti-inflammatory, reparative and neuroprotective functions. Increased levels of TGFbeta in Alzheimer disease (AD) are associated with perivascular deposition of extracellular matrix, which may impair clearance of beta-amyloid and contribute to the development of cerebral amyloid angiopathy. TGFbeta signaling is transduced...
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The two pathognomonic lesions in the brain of AD patients are senile plaques and intraneuronal neurofibrillary tangles (NFT). Previous studies have demonstrated that amyloid-β (Aβ) is a component of both senile plaques and NFTs, and have showed that intracellular accumulation of Aβ is toxic for cells and precedes the appearance of extracellular amyloid deposits. Here we report that there are nu...
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ژورنال
عنوان ژورنال: Journal of Neuropathology and Experimental Neurology
سال: 2007
ISSN: 0022-3069
DOI: 10.1097/nen.0b013e3180303b93